Common Error 421 Problems
Error 421 Service not available, closing control connection.
Error 421 User limit reached
Error 421 You are not authorized to make the connection
Error 421 Max connections reached
Error 421 Max connections exceeded
Possible Solutions
You can receive that 421 error if the FTP server you are connected to limits the total number of connections available or limits the connections available to one user. There are three things you can do:
Limit the number of connections to any one FTP site by selecting Tools > Global Options > Connection and set "Per site max connections /transfers" to 1 (By default it will be set to 2).
Remove items from the Transfer Queue. The Transfer Queue is where you see items ready for transfer, in transit, or just transferred. Sometimes the Queue Pane can become cluttered with unfinished transfers. To clear the queue, right-click inside it and choose Remove All.
Make sure only one instance of CuteFTP is running on your system. Open the Windows Task Manager and see if CuteFTP is listed more than once.